Dimethyl sulfoxide (DMSO) is a straightforward and available naturally occurring chemical that quickly enters the physique via the pores and skin and has a wide range of exceptional therapeutic properties. When it was found, its proponents realized it represented a brand new therapeutic precept in drugs and as soon as adopted, would fully change how drugs was practiced.
In flip, they performed 1000’s of research demonstrating DMSO’s overwhelming security and efficacy in a whole bunch of 1000’s of individuals, however sadly, the FDA performed a reprehensible marketing campaign towards DMSO1 that ultimately made it turn into a Forgotten Facet of Drugs.
Within the Sixties a miraculous therapy for persistent ache, traumatic damage, strokes and spinal wire paralysis was found that unfold throughout America like wildfire—till the FDA buried it.
Right here, 60 Minutes uncovered the FDA utilizing the identical playbook they used all through COVID-19. A🧵 pic.twitter.com/Bh0dcjNk5w
— A Midwestern Physician (@MidwesternDoc) October 14, 2024
During the last month, I’ve begun presenting that proof. For instance:
- I confirmed here how DMSO transforms the administration of strokes, spinal wire accidents, psychological incapacity and a wide range of circulatory issues (e.g., Raynaud’s, Varicose Veins and Hemorrhoids).
- I confirmed here how DMSO treats persistent ache, arthritis, burns, wounds and traumatic accidents (e.g., sprains and sports activities accidents) right here.
- I confirmed here how DMSO is among the most secure medical substances in existence.
In flip, colleagues similar to Pierre Kory have begun utilizing DMSO and reporting exceptional outcomes. Likewise, I’ve acquired a whole bunch of extraordinary tales from readers who’ve gotten their lives again due to DMSO (which may be learn here) and match precisely what the early pioneers of DMSO noticed. As we speak, I’ll concentrate on a few of the different vital makes use of for DMSO.
Observe: Whereas I’ve my own preferred brands of DMSO, most formulations work. When buying DMSO, if getting the liquid kind, you will need to make certain the DMSO is of excessive purity and saved in a glass container (the gel kind additionally works and is simpler to use however can be extra prone to be irritating and never at all times as potent).
When making use of DMSO topically, you will need to ensure you aren’t allergic to it (with a small pores and skin take a look at), that your pores and skin is clear (so no chemical toxins are by accident absorbed as effectively) and to solely use the utmost focus one’s pores and skin simply tolerates (which usually is 70% however can range from 30% to 100%).
DMSO and Protein Problems
DMSO presents a groundbreaking method to treating advanced diseases by stabilizing misfolded proteins,2 a key problem in lots of genetic issues. In contrast to expensive medication that try to handle these issues with restricted success, DMSO’s protein-folding assist can deal with a broad vary of situations, together with cystic fibrosis,3 amyloidosis4,5,6,7 and even difficult neurological illnesses.8,9,10 DMSO’s impact right here is remarkably common.
Observe: Improving the physiologic zeta potential (an method we sometimes use to deal with circulatory issues) also can stabilize protein folding (whereas worsening it causes aggregation and misfolding). Likewise, DMSO has been proven11 to dissolve quite a few enzymes with out irreversibly inhibiting them, which authors felt recommended DMSO may compensate for genetically faulty enzymes.12
Remarkably, DMSO has proven promise in treating prion illnesses like Creutzfeldt-Jakob,13 Alzheimer’s,14 and Parkinson’s. Testimonials reveal DMSO’s energy, with stories of improved motion, power, and coordination. For instance, one reader utilizing it for Parkinson’s skilled lowered stiffness, sooner motion, and improved motor expertise.15
Whereas I’m very open-minded to unconventional medical concepts and knew DMSO may deal with a wide range of in any other case incurable neurological illnesses (e.g., ALS), there was one factor I at all times had a little bit of problem believing.
DMSO allegedly had been proven to remedy Down Syndrome, demonstrated each in three scientific trials16,17,18 and memorable case stories19 that had been introduced by a number of corroborating medical witnesses in Congressional testimony, together with quite a few research displaying DMSO improved the cognition and habits of developmentally delayed kids.20,21,22,23
To elucidate this not possible profit, I theorized it was seemingly because of DMSO’s protein stabilizing advantages, as Down Syndrome is characterised by “the aberrant accumulation of unfolded/misfolded proteins ensuing from over-burdened protein high quality management programs.”24
What I discover significantly noteworthy about that is that the “untreatability” of genetic issues (which usually outcome from a dysfunctional protein) has justified spending unimaginable quantities of cash on each analysis and coverings for them (e.g., the business continues to be in its early levels however 20.4 billion is already spent every year on gene therapies in the USA25 — which partially explains why there was such a push to deliver the unsafe mRNA platform onto the market and open up a large new drug sector).
In distinction, DMSO is just about free and has been proven to deal with many of those issues we nonetheless should not have a superb possibility for.
Collagen Problems
Irregular collagen buildup contributes to many illnesses, together with rheumatologic and degenerative getting old situations. DMSO, recognized for addressing protein buildup, additionally “softens” collagen, benefiting varied collagen issues. It helps by:
- Regulating MMP-9 exercise to assist orderly therapeutic, decreasing fibrotic illnesses.26
- Lowering adhesions from surgical procedure27 and eliminating radiation-induced fibrosis.28
- Treating keloids29 by loosening collagen bundles30 to flatten scars.
- Strengthening incisions31 and scars to forestall extreme scar formation32 post-surgery.
Observe: Many different stories of DMSO benefitting collagen issues (e.g., this symposium, which supplied knowledge on 9,521 sufferers with a wide range of situations similar to Dupuytren’s contractures33) additionally exist.
DMSO has proven promising results on collagen-related issues like Dupuytren’s and Peyronie’s, each of which contain irregular collagen buildup. Early research, together with one from 1965,34 confirmed that DMSO improved vary of movement in scleroderma and lowered plaque in Dupuytren’s contracture.
Dupuytren’s Contracture
This situation includes thickened collagen within the palm, inflicting finger contractures. Normal therapies like collagen-digesting injections, needle aponeurotomy, or surgical procedure can have problems and excessive recurrence charges.35 Early stories famous that long-term DMSO use led to enhancements, with 3 out of three sufferers responding positively in a single research,36 and partial or full remissions in others.37
Nonetheless, effectiveness appears greater when DMSO is used early, at greater concentrations, and over a protracted interval.
Peyronie’s Illness
Peyronie’s causes painful scarring and curvature of the penis, and whereas therapies exist, they typically do not absolutely resolve the problem. DMSO, particularly when utilized early, has been reported to cut back plaque dimension and ache. Notably, Dr. Stanley Jacob in Portland noticed aid in about half of his sufferers.38 Analysis from the Cleveland Urologists discovered that 6 of 13 males noticed sufficient enchancment to renew regular intercourse,39 with some experiencing lowered plaques and even full decision.
Observe: Whereas DMSO doesn’t have a 100% remedy price for Dupuytren’s or Peyronie’s, it typically works and in contrast to the opposite choices is devoid of unwanted side effects. As a result of DMSO works finest when used early and may be utilized discreetly at residence, it presents a robust and accessible possibility for these coping with these situations — particularly Peyronie’s illness.
Rheumatoid Arthritis Contractures
DMSO has additionally confirmed helpful for flexion contractures from rheumatoid arthritis, the place it elevated joint flexibility by 20 to 30 levels with out relapse after a follow-up.40
Fibrodysplasia Ossificans Progressiva (FOP)
FOP, a uncommon genetic dysfunction inflicting muscular tissues and ligaments to progressively flip into bone, is often thought of terminal and incurable. But, sufferers in research have improved from DMSO (e.g., one regained some shoulder and hand motion and noticed smaller calcified lumps).41
Scleroderma
“In the course of the eight months I’ve been testing DMS:
- I’ve been capable of stroll and drive a automotive (I had been consigned to a wheelchair by docs on the College of Michigan Medical Middle)
- My horrible swallowing drawback because of a calcified esophagus has improved, though I nonetheless eat child meals meats
- I nonetheless have 9 fingers left, free so removed from amputation
I am combating for a change in drug analysis to present 1000’s of different individuals a way forward for some promise.”42
Scleroderma is a devastating illness characterised by hardening and thickening of the pores and skin, beginning with blood vessels and probably spreading to muscular tissues, joints, and inner organs, the place it typically turns into deadly.43 Regardless of years of analysis, choices stay restricted, with poor survival charges and frequent problems like ulcers, impaired mobility, and lack of fingers or toes because of poor circulation.44
Early analysis discovered DMSO to be remarkably useful for scleroderma, typically prompting affected person protests towards the FDA’s refusal to approve it.45 Research confirmed DMSO’s effectiveness in therapeutic ulcers, softening hardened pores and skin, enhancing circulation, and even decreasing collagen buildup.
In a landmark research of 42 scleroderma sufferers,46 62% skilled notable enhancements, with a couple of even attaining remission. Many sufferers needed to proceed DMSO use to take care of advantages, however the outcomes had been life-changing.
Observe: This research was initially impressed by the popularity that DMSO is very effective at treating pain, and scleroderma is commonly fairly painful.
In a later research on the Cleveland Clinic, DMSO elevated joint flexibility, restored pores and skin suppleness, and improved grip energy.47 Russian researchers additionally noticed speedy enhancements in over 90% of scleroderma sufferers, with many experiencing no relapses as much as 5 years later.48
Testimonials from sufferers, together with a passionate plea earlier than Congress, highlighted DMSO’s potential as a secure and impactful therapy — although it is nonetheless uncommon for contemporary rheumatologists to know a lot about it.49 Moreover, quite a few rheumatologists surveyed by Congress discovered it efficient for scleroderma.50
Different Autoimmune Situations
Within the first two elements of this collection51,52 I supplied intensive analysis demonstrating DMSO’s capability to forestall or resolve experimentally induced irritation (or tissue necrosis) and analysis mapping out DMSO’s particular anti-inflammatory properties (e.g., it inhibits quite a few inflammatory cytokines), and a wealth of information displaying it was an efficient therapy for rheumatoid arthritis.
DMSO in flip, is effectively acknowledged for its anti-inflammatory actions, and a few of my colleagues have used it for this objective for years. Likewise, many authors have mentioned its use in a wide range of autoimmune issues (e.g., this writer mentioned how DMSO can typically be fairly useful for idiopathic thrombocytopenic purpura53). Within the part under, I’ll talk about its use in a couple of key autoimmune situations.
1. Interstitial cystitis (IC)
• Overview — IC, often known as painful bladder syndrome, can drastically have an effect on high quality of life, resulting in frequent and pressing urination — generally as much as 50 instances a day — typically accompanied by pelvic ache, bladder irritation, and even blood within the urine.
• DMSO therapy — Administered as RIMSO-50, DMSO has FDA approval particularly for IC. It really works by assuaging ache54 and decreasing irritation55 within the bladder wall, selling leisure of bladder muscular tissues56 and stopping scar tissue formation.57
• Outcomes — Scientific stories present that many sufferers expertise substantial aid, with response charges various between research however typically demonstrating a big discount in signs similar to ache and urgency.58,59,60,61,62
2. Lupus
• Overview — Lupus is a fancy autoimmune illness that may trigger widespread irritation and harm to varied physique programs. Sufferers typically battle with persistent signs and discover conventional therapies insufficient.
• DMSO purposes — Reviews counsel that DMSO might successfully alleviate signs in lupus sufferers, even these unresponsive to steroids. Notably, some circumstances have proven DMSO resulting in remission of lupus-related interstitial cystitis,63 demonstrating its multifaceted advantages.
• Potential influence — As a possible different or adjunct remedy,64 DMSO presents hope for these in search of higher administration of their lupus signs.
3. Bronchial asthma
• Overview — Bronchial asthma is characterised by irritation and narrowing of the airways, resulting in problem respiratory. Conventional therapies typically depend on bronchodilators and corticosteroids.
• DMSO advantages — Analysis signifies that DMSO might scale back the severity of bronchial asthma signs, significantly when used along side different therapies. Some research report65 that DMSO can lower the frequency and dosage of bronchial asthma drugs required, with some sufferers even eliminating the necessity for drugs altogether.
• Influence — This might considerably improve the standard of life for bronchial asthma victims, offering them with extra management over their situation.
4. A number of sclerosis (MS)
• Overview — MS is a persistent illness affecting the central nervous system, resulting in a spread of neurological signs that may range enormously between people and infrequently can’t be absolutely managed with standard care.
• DMSO advantages — A Russian research of 34 MS sufferers discovered DMSO supplied vital profit to them.66
• DMSO case research — Anecdotal proof reveals that some MS sufferers have skilled exceptional enhancements following DMSO therapy.67
Observe: There was additionally a reported case68 of Stanley Jacob treating a affected person with ALS which resulted in “some instantaneous, in a single day and barely delayed wonders of remedy,” and this consumer reported69 she noticed it visibly enhance the situation. In our personal expertise IV DMSO is among the solely issues which may deal with ALS (sometimes it halts the development of the illness).
5. Uveitis
• Overview — Uveitis is an irritation of the center layer of the attention, which may trigger ache, mild sensitivity, and imaginative and prescient adjustments.
• DMSO analysis — Research performed on canines with uveitis have proven that DMSO successfully reduces each irritation and intraocular stress.70
• Human utility potential — This promising analysis means that DMSO may very well be explored as a therapy possibility for people affected by comparable inflammatory eye situations, significantly since DMSO treats many different ocular issues.
6. Inflammatory bowel illnesses (IBD)
• Overview — Situations like gastritis, ulcerative colitis and Crohn’s illness result in persistent irritation of the digestive tract, leading to signs like belly ache, diarrhea, and fatigue.
• Efficacy of DMSO — Analysis highlights DMSO’s potential to cut back relapse charges and inflammatory markers when added to plain therapies for ulcerative colitis.71
• Scientific significance — By enhancing the effectiveness of current therapies, DMSO might present a pathway to higher administration of IBD72 and improved affected person outcomes. Lots of my colleagues discover DMSO is exceptionally useful for IBD.
7. Myasthenia gravis (MG)
• Overview — MG is an autoimmune dysfunction that impacts communication between nerves and muscular tissues, resulting in weak point and fatigue.
• DMSO mechanism — Animal research point out that DMSO can scale back ranges of acetylcholine receptor antibodies,73 which play an important position within the illness’s pathology.
• Future instructions — Whereas human research are missing, this analysis opens the door for potential therapeutic methods involving DMSO in managing MG.
Observe: DMSO has additionally been proven to suppress thyroid autoantibodies74 (a typical explanation for hypothyroidism).
8. Sjogren’s syndrome — Sjogren’s syndrome (autoimmunity of the parotid gland) ends in a lack of saliva and the mouth turning into very dry. Since it’s a very tough situation to deal with, this desk inside a bigger research75 caught my eye:
Conclusion
On the time these discoveries had been made greater than fifty years in the past, they had been revolutionary, many nonetheless are (e.g., standard drugs nonetheless can’t deal with lots of the situations described right here and clinically, DMSO stays probably the most anti-inflammatory brokers out there to us).
As a result, many physicians and desperate patients from around the country fought to make DMSO be legalized, however exterior of its slender indication for interstitial cystitis, the FDA refused to relent76 — even after many congressional representatives and senators spent a long time making an attempt to power the FDA to.
Fairly, it was solely after the general public turned so disgusted with the FDA conducting police type raids towards pure drugs and Congress handed the 1994 DSHEA Act77 which prohibited the FDA from regulating naturally occurring dietary supplements that issues modified (as DMSO happens in nature).
Sadly, by the point this occurred, the harm was completed and only a few remembered the unimaginable potential DMSO needed to rework your complete apply of drugs — regardless of the very fact a whole bunch of 1000’s of Individuals had been utilizing DMSO within the not too distant previous.
Worse nonetheless, these monopolistic ways by no means stopped, and so many exceptional therapies which may have helped all of humanity have been erased by the medical business (e.g., contemplate how onerous the FDA fought to bury hydroxychloroquine and ivermectin throughout COVID-19 so the unconscionable mRNA vaccines would face no competitors).
Fortuitously (because of the speedy diffusion of data facilitated by social media), these ways have provoked such a powerful backlash that a unprecedented, a once-in-a-lifetime alternative has been created, and subsequent week we’ll eventually have an opportunity to repair this dysfunctional paradigm:
FDA’s struggle on public well being is about to finish. This contains its aggressive suppression of psychedelics, peptides, stem cells, uncooked milk, hyperbaric therapies, chelating compounds, ivermectin, hydroxychloroquine, nutritional vitamins, clear meals, sunshine, train, nutraceuticals and something…
— Robert F. Kennedy Jr (@RobertKennedyJr) October 25, 2024
In flip, I really feel extremely blessed to dwell in an period the place The Forgotten Sides of Drugs can eventually be rediscovered and to have been given the chance by the pure well being neighborhood to assist make that occur. For many years I by no means imagined what we’re seeing now may ever be doable.
Writer’s notice: That is an abridged model of a longer article that goes into better element on the factors talked about right here, examines the bizarre mechanisms that permit DMSO to deal with so many various inflammatory situations, and supplies steerage for private DMSO use (e.g., dosing, therapeutic precautions and the place to acquire it).
That article and its further references may be learn here (together with a companion article discussing DMSO’s life-changing utility for a wide range of musculoskeletal accidents and persistent ache situations).
A Observe from Dr. Mercola Concerning the Writer
A Midwestern Physician (AMD) is a board-certified doctor from the Midwest and a longtime reader of Mercola.com. I admire AMD’s distinctive perception on a variety of subjects and am grateful to share it. I additionally respect AMD’s need to stay nameless since AMD continues to be on the entrance strains treating sufferers. To seek out extra of AMD’s work, you’ll want to take a look at The Forgotten Side of Medicine on Substack.
